Regulation of drug-metabolizing enzymes by sex-related...

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Regulation of drug-metabolizing enzymes...

Regulation of drug-metabolizing enzymes by sex-related hormones: clinical implications for transgender medicine

An Le, Kai J Huang, Lauren R Cirrincione

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ఈ పుస్తకం ఎంతగా నచ్చింది?

దింపుకొన్న ఫైల్ నాణ్యత ఏమిటి?

పుస్తక నాణ్యత అంచనా వేయడాలనుకుంటే దీన్ని దింపుకోండి

దింపుకొన్న ఫైళ్ళ నాణ్యత ఏమిటి?

Transgender medicine is a diverse and growing clinicalfield with unmet gaps in
pharmacological knowledge. Hormone therapy (testosterone or estrogen treat-
ment), one part of the standard of medical care for transgender adults, aligns
secondary sex characteristics with an individual’s gender identity and expres-
sion. Despite established effects of sex steroids on drug-metabolizing enzyme
expression and activityin vitroand in animal models, the effect of long-term,
supraphysiological sex hormone treatment on drug metabolism in transgender
adults is not yet established. Here, we synthesize availablein vitroand animal
model data with pharmacological concepts in transgender medicine to predict
potential effects of sex steroids on drug-metabolizing enzymes, and their rela-
tionship with potential hormone–drug interactions, in transgender medicine.

వర్గాలు:

Medicine - Trial

సంవత్సరం:

2022

భాష:

english

పేజీల సంఖ్య:

ఫైల్:

PDF, 1.65 MB

IPFS:

english, 2022

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